| Player | TM | Wk15 | Wk16 | Wk17 | Wk18 | Wk19 | Wk20 | Wk21 | Targ | T/TmG | T/G | REC | YD | Y/R | TD | Rec% |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Michael Thomas | 12 | 17 | 9 | 8 | dnp | dnp | dnp | 194 | 0.0 | 11.4 | 156 | 1795 | 11.5 | 9 | 80.4 | |
| DeAndre Hopkins | TEN | 8 | 9 | 0 | 8 | 14 | dnp | - | 172 | 9.1 | 9.6 | 119 | 1373 | 11.5 | 7 | 69.2 |
| Travis Kelce | KC | 13 | 9 | 5 | - | 12 | 4 | 6 | 158 | 8.3 | 8.3 | 116 | 1436 | 12.4 | 9 | 73.4 |
| Christian McCaffrey | SF | 10 | 15 | 10 | - | dnp | dnp | dnp | 143 | 7.5 | 8.9 | 116 | 1005 | 8.7 | 4 | 81.1 |
| Keenan Allen | CHI | 10 | 10 | 10 | - | - | - | - | 150 | 9.4 | 9.4 | 104 | 1199 | 11.5 | 6 | 69.3 |