FBG says: Neutral matchup. Arizona's backfield has been banged-up in recent weeks, with both David Johnson and Chase Edmonds missing time. Edmonds will likely miss this week's game as well, resting a hamstring injury through the team's week 12 bye, but David Johnson should be good to go alongside recent trade acquisition Kenyan Drake. Drake out-snapped Johnson last weekend against the Tampa Bay Buccaneers, as Johnson posted just two rushing yards on five attempts in the game. Drake finished the day with 35 rushing yards on 10 carries, a respectable encore to his 15-carry, 110-yard debut with the team against the 49ers just 2 weeks ago. The Cardinals are a pass-heavy offensive team, and a split workload between David Johnson and Kenyan Drake muddies up an already volatile situation. Arizona's offensive line has struggled to clear rushing lanes for the Cardinals' rushing attack this season. A soft matchup against the 49ers' vulnerable run defense should help Arizona's efficiency on the ground, but projecting the work between the two backs is a challenging task entering the week.
The San Francisco 49ers' run defense has face minimal volume on the ground this season, as they have forced their opposition into consistent pass-heavy attacks while playing from behind. When their opponents have elected to run the ball, however, they have seen success, posting 4.6 yards per carry so far this season, the 9th highest total in the NFL. The 49ers' defensive line is loaded with pass-rushing talent, but Arik Armstead stands out as the only formidable run stopper of the bunch. Then, he gets little support at the second-level of the defense, where linebackers Fred Warner and Dre Greenlaw have failed in their run-stopping duties this season. Warner has struggled against the run throughout his career, failing to fill running lanes and finish tackles, while Greenlaw's shortcomings are primarily a product of inexperience. Greenlaw was drafted in the fifth round of the NFL Draft this past year, and he was forced into a starting role after the team's original starter, Kwon Alexander went down for the season with a torn pectoral. Jimmie Ward stands out at the safety position as a top-end run-stopper in the secondary for the 49ers, but unfortunately, that is not enough to bolster one of the NFL's weaker run-stopping units overall. The Arizona Cardinals posted 153 rushing yards on this defense just 2 weeks ago, and they have an excellent opportunity to eclipse the century mark on the ground once again here in week 11.