FBG says: Tough matchup. The San Francisco offense is a decidedly run-dominant one, which is no surprise under coach Kyle Shanahan. And try as he might, he can no longer ignore the impact that Raheem Mostert has made on an attack that had stagnated by midseason. Over the past 3 weeks, with Matt Breida injured and Tevin Coleman running on fumes (2.1 yards per carry), Mostert has turned 31 rushes into 204 yards and 2 touchdowns. Dating back to last season, over 20 games in this offense, Mostert has posted a wild 6.3 yards a carry. This remains a multi-headed backfield, especially with Breida looking probable to return for Sunday. With the opportunity likely to be spread so thin, it's hard to project much volume for any of the three. But for fantasy players not averse to risk, Mostert does look like the strongest option. His role may actually be the stablest right now, and there's no denying his dynamism as a big-play magnet.
Due to a variety of factors, the New Orleans run defense remains one of fantasy's toughest matchups. Game flow tends to favor the 10-2 Saints, keeping volume and production down for their opponents. And it's a strong unit to boot, anchored by an underrated front line capable of controlling the point of attack. The second level is a bit inconsistent, but has a few run-stuffing stars, including potential All-Pro Demario Davis at linebacker. Altogether, they've allowed just 2 runners to top 70 yards in a game, stifling the likes of Christian McCaffrey (64), Ezekiel Elliott (35), and Chris Carson (53) along the way. The 49ers boast a dynamic ground game, but they'll have to take control of the game early to reap the rewards in this matchup.